Gene Expression Literature Summary

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Nr5a1  nuclear receptor subfamily 5, group A, member 1   (Synonyms: Ad4BP, adrenal 4-binding protein, ELP, Ftzf1, Ftz-F1, SF1, SF-1, steroidogenic factor 1)
Results	Reference
1	J:311885 Bandiera R, Vidal VP, Motamedi FJ, Clarkson M, Sahut-Barnola I, von Gise A, Pu WT, Hohenstein P, Martinez A, Schedl A, WT1 maintains adrenal-gonadal primordium identity and marks a population of AGP-like progenitors within the adrenal gland. Dev Cell. 2013 Oct 14;27(1):5-18
1	J:104330 Barrionuevo F, Bagheri-Fam S, Klattig J, Kist R, Taketo MM, Englert C, Scherer G, Homozygous Inactivation of Sox9 Causes Complete XY Sex Reversal in Mice. Biol Reprod. 2006 Jan;74(1):195-201
1	J:89122 Bland ML, Fowkes RC, Ingraham HA, Differential requirement for steroidogenic factor-1 gene dosage in adrenal development versus endocrine function. Mol Endocrinol. 2004 Apr;18(4):941-52
1	J:237198 Burton RF, Relationships among fat mass, fat-free mass and height in adults: A new method of statistical analysis applied to NHANES data. Am J Hum Biol. 2017 May 6;29(3)
1	J:269807 Correa SM, Newstrom DW, Warne JP, Flandin P, Cheung CC, Lin-Moore AT, Pierce AA, Xu AW, Rubenstein JL, Ingraham HA, An estrogen-responsive module in the ventromedial hypothalamus selectively drives sex-specific activity in females. Cell Rep. 2015 Jan 6;10(1):62-74
1	J:306254 Crane-Smith Z, Schoenebeck J, Graham KA, Devenney PS, Rose L, Ditzell M, Anderson E, Thomson JI, Klenin N, Kurrasch DM, Lettice LA, Hill RE, A Highly Conserved Shh Enhancer Coordinates Hypothalamic and Craniofacial Development. Front Cell Dev Biol. 2021;9:595744
1	J:310001 Ikeda Y, Tagami A, Komada M, Takahashi M, Expression of Kisspeptin in Gonadotrope Precursors in the Mouse Pituitary during Embryonic and Postnatal Development and in Adulthood. Neuroendocrinology. 2017;105(4):357-371
1	J:303384 Ikeda Y, Tagami A, Maekawa M, Nagai A, The conditional deletion of steroidogenic factor 1 (Nr5a1) in Sox9-Cre mice compromises testis differentiation. Sci Rep. 2021 Feb 24;11(1):4486
1	J:101320 Jeanes A, Wilhelm D, Wilson MJ, Bowles J, McClive PJ, Sinclair AH, Koopman P, Evaluation of candidate markers for the peritubular myoid cell lineage in the developing mouse testis. Reproduction. 2005 Oct;130(4):509-16
1	J:155826 King P, Paul A, Laufer E, Shh signaling regulates adrenocortical development and identifies progenitors of steroidogenic lineages. Proc Natl Acad Sci U S A. 2009 Dec 15;106(50):21185-90
1	J:194924 Lavery R, Chassot AA, Pauper E, Gregoire EP, Klopfenstein M, de Rooij DG, Mark M, Schedl A, Ghyselinck NB, Chaboissier MC, Testicular differentiation occurs in absence of R-spondin1 and Sox9 in mouse sex reversals. PLoS Genet. 2012;8(12):e1003170
1	J:241571 Lin YT, Barske L, DeFalco T, Capel B, Numb regulates somatic cell lineage commitment during early gonadogenesis in mice. Development. 2017 May 01;144(9):1607-1618
1	J:192186 Maatouk DM, Mork L, Hinson A, Kobayashi A, McMahon AP, Capel B, Germ cells are not required to establish the female pathway in mouse fetal gonads. PLoS One. 2012;7(10):e47238
1	J:222626 McClelland KS, Bell K, Larney C, Harley VR, Sinclair AH, Oshlack A, Koopman P, Bowles J, Purification and Transcriptomic Analysis of Mouse Fetal Leydig Cells Reveals Candidate Genes for Specification of Gonadal Steroidogenic Cells. Biol Reprod. 2015 Jun;92(6):145
1	J:322444 Omotehara T, Nakata H, Itoh M, Three-dimensional analysis of mesonephric tubules remodeling into efferent tubules in the male mouse embryo. Dev Dyn. 2022 Mar;251(3):513-524
1	J:213801 Padua MB, Fox SC, Jiang T, Morse DA, Tevosian SG, Simultaneous gene deletion of gata4 and gata6 leads to early disruption of follicular development and germ cell loss in the murine ovary. Biol Reprod. 2014 Jul;91(1):24
1	J:222045 Padua MB, Jiang T, Morse DA, Fox SC, Hatch HM, Tevosian SG, Combined loss of the GATA4 and GATA6 transcription factors in male mice disrupts testicular development and confers adrenal-like function in the testes. Endocrinology. 2015 May;156(5):1873-86
1	J:179464 Paul A, Laufer E, Endogenous biotin as a marker of adrenocortical cells with steroidogenic potential. Mol Cell Endocrinol. 2011 Apr 10;336(1-2):133-40
1	J:168022 Pelling M, Anthwal N, McNay D, Gradwohl G, Leiter AB, Guillemot F, Ang SL, Differential requirements for neurogenin 3 in the development of POMC and NPY neurons in the hypothalamus. Dev Biol. 2011 Jan 15;349(2):406-16
1	J:343800 Souali-Crespo S, Condrea D, Vernet N, Feret B, Klopfenstein M, Grandgirard E, Alunni V, Cerciat M, Jung M, Mayere C, Nef S, Mark M, Chalmel F, Ghyselinck NB, Loss of NR5A1 in mouse Sertoli cells after sex determination changes cellular identity and induces cell death by anoikis. Development. 2023 Dec 15;150(24)
1	J:143587 Tang H, Brennan J, Karl J, Hamada Y, Raetzman L, Capel B, Notch signaling maintains Leydig progenitor cells in the mouse testis. Development. 2008 Nov;135(22):3745-53
1	J:78688 Tevosian SG, Albrecht KH, Crispino JD, Fujiwara Y, Eicher EM, Orkin SH, Gonadal differentiation, sex determination and normal Sry expression in mice require direct interaction between transcription partners GATA4 and FOG2. Development. 2002 Oct;129(19):4627-34
1	J:224628 Tevosian SG, Jimenez E, Hatch HM, Jiang T, Morse DA, Fox SC, Padua MB, Adrenal Development in Mice Requires GATA4 and GATA6 Transcription Factors. Endocrinology. 2015 Jul;156(7):2503-17
1	J:233303 Vidal V, Sacco S, Rocha AS, da Silva F, Panzolini C, Dumontet T, Doan TM, Shan J, Rak-Raszewska A, Bird T, Vainio S, Martinez A, Schedl A, The adrenal capsule is a signaling center controlling cell renewal and zonation through Rspo3. Genes Dev. 2016 Jun 15;30(12):1389-94
1	J:139698 Wataya T, Ando S, Muguruma K, Ikeda H, Watanabe K, Eiraku M, Kawada M, Takahashi J, Hashimoto N, Sasai Y, Minimization of exogenous signals in ES cell culture induces rostral hypothalamic differentiation. Proc Natl Acad Sci U S A. 2008 Aug 19;105(33):11796-801
1*	J:149243 Wilhelm D, Washburn LL, Truong V, Fellous M, Eicher EM, Koopman P, Antagonism of the testis- and ovary-determining pathways during ovotestis development in mice. Mech Dev. 2009 May-Jun;126(5-6):324-36
1	J:109014 Wilson MJ, Bowles J, Koopman P, The matricellular protein SPARC is internalized in Sertoli, Leydig, and germ cells during testis differentiation. Mol Reprod Dev. 2006 May;73(5):531-9
1*	J:96928 Wilson MJ, Jeyasuria P, Parker KL, Koopman P, The transcription factors steroidogenic factor-1 and SOX9 regulate expression of Vanin-1 during mouse testis development. J Biol Chem. 2005 Feb 18;280(7):5917-23
1	J:99574 Wilson MJ, Liaw L, Koopman P, Osteopontin and related SIBLING glycoprotein genes are expressed by Sertoli cells during mouse testis development. Dev Dyn. 2005 Aug;233(4):1488-95
1	J:152917 Zubair M, Oka S, Parker KL, Morohashi K, Transgenic expression of Ad4BP/SF-1 in fetal adrenal progenitor cells leads to ectopic adrenal formation. Mol Endocrinol. 2009 Oct;23(10):1657-67